Protein abundance is governed by the complex interplay between RNA expression and post-transcriptional processes including translation. In a typical eukaryotic cell, a particular gene might be expressed at an absolute mRNA copy number of a single molecule to ~1000 molecules. Yet, the dynamic range of proteins in individual cells is ~100 – 1,000,000 copies. Translation efficiency, i.e. the number of proteins synthesized per mRNA, is a major contributor to determining protein abundance. Our long-term goal is to develop the necessary computational and experimental framework that will enable quantitative and reproducible determination of translational control.

You can find more details about some of our ongoing research projects here:

A computational ecosystem to understand translational control

A platform for discovery of trans-acting translation regulators

Ultra-low input ribosome profiling for characterizing translation in development, cancer and immunology